Production of Experimental Cholesterol-Induced Atherosclerosis in Chicks with Minimal Hypercholesterolemia and Organ Lipidosis
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چکیده
منابع مشابه
Production of experimental cholesterol-induced atherosclerosis in chicks with minimal hypercholesterolemia and organ lipidosis.
C HRONIC cholesterol feeding leads to the development of atherosclerosis in the chick."' 2 In all our previous studies, marked hypercholesterolemia and organ lipidosis were consistent concomitants of this cholesterol-induced atheromatosis.'Human atherosclerosis frequently occurs in people with presumably normal plasma and tissue cholesterol levels. Ostensibly cholesterol metabolism is not deran...
متن کاملProduction of Experimental Cholesterol - In - duced Atherosclerosis in Chicks with Minimal Hypercholesterolemia and Organ Lipidosis
C HRONIC cholesterol feeding leads to the development of atherosclerosis in the chick."' 2 In all our previous studies, marked hypercholesterolemia and organ lipidosis were consistent concomitants of this cholesterol-induced atheromatosis.'Human atherosclerosis frequently occurs in people with presumably normal plasma and tissue cholesterol levels. Ostensibly cholesterol metabolism is not deran...
متن کاملEstrogen-induced regression of coronary atherosclerosis in cholesterol-fed chicks.
The present study demonstrates that estrogens reverse previously induced coronary atherosclerosis in cholesterol-fed cockerels, despite the continued presence of the atherogenic stimulus in the diet. Aorta atherogenesis remains unaffected. Hypercholesterolemia is moderately enhanced by estrogen administration; total cholesterol-lipid phosphorus (C/P) ratios are depressed to normal levels, conse...
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Rabbits were fed either 2 g cholesterol in 10 ml olive oil daily with normal diet (n = 5) or normal diet alone (n = 5). After 12 weeks, the cholesterol-fed animals had developed fatty plaques involving 24% +/- 4% of the surface area of the aorta; the control animals had none. Mean platelet volume was significantly smaller (p less than 0.04) in the cholesterol-fed animals (4.1 +/- 0.3 fl) compar...
متن کاملIncreased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits.
OBJECTIVE Endothelial lipase (EL) is a key determinant in plasma high-density lipoprotein-cholesterol. However, functional roles of EL on the development of atherosclerosis have not been clarified. We investigated whether hepatic expression of EL affects plasma lipoprotein metabolism and cholesterol diet-induced atherosclerosis. APPROACH AND RESULTS We generated transgenic (Tg) rabbits expres...
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ژورنال
عنوان ژورنال: Circulation
سال: 1950
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.2.5.705